A miniscule, translucent Zebrafish which glows fluorescent green when its liver makes glucose has shed some light on metabolism. The fish have helped scientists to find compounds linked with the regulation of metabolism with a view to help treat metabolic disorders.
2,400 compounds were tested on the Zebrafish and two of these were found to successfully switch on a handful of genes which caused the animals to burn fat as a way of producing energy.
The study is in its early stages, but the first of the two compounds has been tested on obese mice. They were affectively shielded from symptoms associated with metabolic disorders. This is a possible breakthrough which could mean effective treatment for obesity, type 2 diabetes and metabolic syndrome.
- Led by scientists at the University of California, San Fransisco. Published in Nature Chemical Biology journal.