Specific Protein Key In Fight Against Obesity

Researchers have identified a protein which controls the metabolism of fat and therefore impacts on insulin resistance and weight control. This discovery is set to aid development of preventative drugs and drugs for the treatment of obesity.

The protein known as TRIP-Br2 is a master regulator responsible for coordinating gene expression and the regulation of fat storage and release from cells. When it is functioning normally, it restricts the amount of fat that cells burn as energy. When the protein is not present, a fat burning ‘frenzy’ occurs which can help those who are obese to shed pounds of fat without being restricted to a minimal rate of fat burning. Scientists are hoping to use this information to make a significant impact on the obesity crisis.


Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Bluher M, Hsu SH, Kulkarni RN, Ablation of TRIP-Br2, a Regulator of Fat Lipolysis, Thermogenesis and Oxidative Metabolism, Prevents Diet-Induced Obesity and Insulin Resistance, Nature Medicine, 2013; DOI:10.1038/nm.3056.

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Job Role Sports Nutritionist and Social Media Coordinator Qualifications Bsc Sport and Exercise Science Steph has a competitive athletic background which spans 19 years. As a child she performed with the English Youth Ballet and had performed on the West End stage by the age of 10. Her enthusiasm for sport and fitness continued to grow as she did, encouraging her to learn more about nutrition and training. She began using her knowledge and personal experience to help others when she began coaching at the age of 16. From here, she went on to study Sport and Exercise Science at the University of Essex during which time she also received the Most Promising Newcomer Award from her University to mark her outstanding contribution to sport. During her first year of study she was introduced to partner stunt acrobatics and artistic gymnastics. After one year of dedicating herself to a lifestyle revolving around her sport, she was training with the best team in the UK who are currently ranked fifth in the world. Steph has worked in both the private and public sector coaching children and adults from grassroot to elite level as well as providing them with cutting edge advice on how to reach their goals. Steph has received awards for her choreography and has competed nationally and internationally meaning that she can back up her scientific knowledge with a wealth of experience. As our resident Sports Nutritionist, Steph is here to provide the most current and evidence based fitness, health and nutrition information to help you reach your health and fitness goals.
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