Researchers have identified a protein which controls the metabolism of fat and therefore impacts on insulin resistance and weight control. This discovery is set to aid development of preventative drugs and drugs for the treatment of obesity.
The protein known as TRIP-Br2 is a master regulator responsible for coordinating gene expression and the regulation of fat storage and release from cells. When it is functioning normally, it restricts the amount of fat that cells burn as energy. When the protein is not present, a fat burning ‘frenzy’ occurs which can help those who are obese to shed pounds of fat without being restricted to a minimal rate of fat burning. Scientists are hoping to use this information to make a significant impact on the obesity crisis.
Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Bluher M, Hsu SH, Kulkarni RN, Ablation of TRIP-Br2, a Regulator of Fat Lipolysis, Thermogenesis and Oxidative Metabolism, Prevents Diet-Induced Obesity and Insulin Resistance, Nature Medicine, 2013; DOI:10.1038/nm.3056.