Vitamin A Derivative Might Treat Type 2 Diabetes…

Researchers at the University of Montreal and CHUM Research Centre (CRCHUM) have recently harnessed retinoic acid, a derivative of vitamin A, and potentially focussed its benefits to treating obesity, diabetes and the associated heart complications that may follow these conditions.

The retinoic acid derived from vitamin A was seen to reduce the risk of cardiac apoptosis (cell death), whilst stimulating the release of cardio- protective genes that were otherwise suppressed by the diseases. It was thought that retinoic acid might also reduce the formation of collagen in the cardiac muscle, this might reduce the onset of fibrosis and potential vascular complications.

Daniel-Constantin Manolescu, one of the first authors of the study explains:

"Blood glucose, insulin resistance, body weight, and adipocyte size were significantly decreased in treated animals, including abdominal fat, while dietary intake and physical activity were similar for treated or non-treated animals. This suggests an increase in basal energy expenditure,"

"Our studies on animals show that retinoic acid induces normalization of blood glucose and reduction of obesity. It is an important contribution to understanding RA action on the liver, fat, muscles, and the heart, and on retinoid metabolism, energy metabolism, fatty acid oxidation, and insulin resistance. Our research identifies new metabolic effects of retinoids and may lead to anti-obesity and anti-diabetic medicines,".


Science Daily, (2014). Vitamin A derivative potentially treats type 2 diabetes, prevents its cardiovascular complications. Retrieved 24th June, 2014, from

About the Author

Job Role Qualified Dietitian and Sports Nutritionist Qualifications BSc (Hons) Sports Science | BSc (Hons) Dietetics Tom has always participated in sport both recreationally and competitively which led to an unquenchable thirst for information on anything health, nutrition and fitness. After leaving school Tom went on to play for a football academy during which time he studied Sport and Exercise Science. From here he went on to study a BSc (Hons) Sport Science at UEA followed by his second BSc (Hons) degree, this time at the University of Hertfordshire studying Dietetics. Tom has worked in the fitness, educational and clinical nutrition industry starting out at David Lloyd Health and Leisure Clubs. He then went on to work as a Dietitian (RD) in the NHS, during which time he conducted clinics for healthy eating, weight loss and weight gain, as well as specialised consultations on Diabetes, IBS and Coeliac disease to name a few. He has vast amounts of experience at devising diet plans and supplement regimens, as well as working in the community with schools and competitive athletes. As Head Nutritionist and Supplement expert at Discount Supplements Tom is here to provide current and evidence based health and nutrition information to help you reach your health and fitness goals!
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