500mg HMB per 2 Capsules
Applied Nutrition HMB is a 120-capsule HMB (beta-hydroxy beta-methylbutyrate) supplement delivering 500mg of HMB per 2-capsule serving. The 120-capsule bottle provides 60 servings.
HMB is a metabolite of the essential amino acid leucine, produced when leucine undergoes transamination and subsequent oxidation. Approximately 5% of dietary leucine is converted to HMB endogenously. HMB inhibits the ubiquitin-proteasome proteolytic pathway — the primary intracellular mechanism responsible for muscle protein degradation — reducing muscle breakdown during calorie deficits, high training volumes and periods of inactivity or illness. This anti-catabolic action is distinct from leucine's anabolic mTORC1 signalling role: HMB primarily reduces degradation, while leucine primarily stimulates synthesis.
The research base for HMB is strongest in three specific populations: untrained individuals beginning a resistance programme (where lean mass preservation during initial muscle damage phases is significant), athletes in calorie-deficit phases where catabolism risk is high, and older adults where muscle protein turnover favours degradation. At 500mg per serving, two servings daily delivers 1g of HMB. The most frequently studied dose in published trials is 3g per day — users seeking the full studied dose would take 6 capsules daily from this product.
HMB 120 Caps suits athletes in cutting phases, those returning from injury with elevated catabolism risk, and individuals running high training volumes where muscle damage accumulation is a concern. It stacks cleanly with creatine, protein and pre-workouts with no interaction risk.
Stack alternative: Applied Nutrition Amino Fuel EAA 390g provides 9g EAAs including 3g leucine — the upstream precursor to HMB — for combined anabolic and anti-catabolic coverage in one product.
